The Effect of Lemon Peel (Citrus limon) Aromatherapy Inhalation as Antidepressant on Rats using Diffuser Method

Abstract. Background Depression is a mood disorder that affects person’s quality of life. This condition influenced by the levels monoamine compounds such as serotonin, norepinephrine, and dopamine in brain. The decrease leads to depressive symptoms. Lemon peel essential oil has an antidepressant potential, contains phytochemicals, d-Limonene, which increase Aromatherapy diffuser inhalation method one kind treatment route depression. mechanism action breaking down smaller particles so they penetrate quicker Objective: To determine effect lemon (Citrus limon) aromatherapy on immobility time white rats (Rattus norvegicus Wistar strain) tail suspension test. Method: True Experimental with Post Test Only Control Group Design. Fifteen male strain were divided into 5 groups. positive control group was given stressors saline induction intraperitoneally. In addition stressors, also at dose 1%, 2.5%, 5%. Measurement carried out hanging rats' tails through test animals stopped moving for least 1 second calculated using timer. Data analyzed ANOVA test, Hoc Pearson correlation Linear Regression Results Discussion: showed significant difference between groups (p = 0.017). post <0.05) P3 (5%). linear regression obtained Adjusted R2 0.598 (inhalation gives 59.8%). due reduction depression caused level induced d-limonene oil. Conclusion: reduces depressed strain).